Probenecid with Oseltamivir for Human Influenza A (H5N1) Virus Infection?
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To the Editor: Probenecid is an inexpensive medication that
was widely used when penicillin was in short supply. Owing to
the current easy access to abundant supplies of penicillin,
this approach is primarily of historical interest. In light
of the limited supply of oseltamivir, however, it may be time
to revisit the use of probenecid as adjunctive therapy for human
influenza A (H5N1) virus infection. Coadministration of oseltamivir
and probenecid has resulted in a reduction in the clearance
of oseltamivir by approximately 50 percent and a corresponding
doubling of the plasma levels of oseltamivir.
1 Therefore, part
of the planning
. . . [Full Text of this Article]
# posted by roodbont @ 2:21 PM
