Wednesday, May 30, 2007
AF en kans op ischemic events
High Risk of Coronary Ischemic Events Seen After First Atrial Fibrillation
Reuters Health Information 2007. © 2007 Reuters Ltd.
Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.
NEW YORK (Reuters Health) May 17 - The risk of coronary ischemic events is high after first atrial fibrillation, according to findings published in the April issue of the American Journal of Medicine.
"Atrial fibrillation (AF) is a growing public health problem that has reached epidemic proportions," Dr. Teresa S. M. Tsang, of the Mayo Clinic, Rochester, Minnesota, and colleagues write. "Although studies have shown that the risk of acute coronary ischemic events at the time of first AF is low, there are no published longer term data."
The researchers examined the long-term, gender-specific incidence and mortality risk of coronary ischemic events after first AF in a community-based, longitudinal study involving 2768 residents of Olmsted County, Minnesota, with AF first documented in 1980 to 2000. The subjects did not have prior coronary heart disease, and were followed to 2004.
During a mean follow-up of 6 years, 463 (17%) of the participants had a first coronary ischemic event. The risk of coronary ischemic events was greatest during the first year.
The unadjusted incidence of coronary ischemic events after AF was 3.1 per 1000 person-years, with no difference between men and women. However, an association was observed between male sex and an increased risk of coronary ischemic events after adjusting for age (hazard ratio 1.32, p = 0.004).
"Restricting the analysis to the subgroup aged 30 to 74 years (n = 1403), the same age range for which the Framingham coronary risk equation was developed, the estimations of coronary event rates at 10 years were 22% for men and 19% for women by Kaplan-Meier analyses, versus 21% for men and 11% for women by Framingham risk equation," Dr. Tsang's team explains.
That is, atrial fibrillation conferred additional risk for coronary events "beyond conventional risk prediction in women only," the investigators point out. Furthermore, they found, the excess mortality risk associated with coronary events after the occurrence of AF was greater in women.
Am J Med 2007;120:357-363.
Reuters Health Information 2007. © 2007 Reuters Ltd.
Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.
NEW YORK (Reuters Health) May 17 - The risk of coronary ischemic events is high after first atrial fibrillation, according to findings published in the April issue of the American Journal of Medicine.
"Atrial fibrillation (AF) is a growing public health problem that has reached epidemic proportions," Dr. Teresa S. M. Tsang, of the Mayo Clinic, Rochester, Minnesota, and colleagues write. "Although studies have shown that the risk of acute coronary ischemic events at the time of first AF is low, there are no published longer term data."
The researchers examined the long-term, gender-specific incidence and mortality risk of coronary ischemic events after first AF in a community-based, longitudinal study involving 2768 residents of Olmsted County, Minnesota, with AF first documented in 1980 to 2000. The subjects did not have prior coronary heart disease, and were followed to 2004.
During a mean follow-up of 6 years, 463 (17%) of the participants had a first coronary ischemic event. The risk of coronary ischemic events was greatest during the first year.
The unadjusted incidence of coronary ischemic events after AF was 3.1 per 1000 person-years, with no difference between men and women. However, an association was observed between male sex and an increased risk of coronary ischemic events after adjusting for age (hazard ratio 1.32, p = 0.004).
"Restricting the analysis to the subgroup aged 30 to 74 years (n = 1403), the same age range for which the Framingham coronary risk equation was developed, the estimations of coronary event rates at 10 years were 22% for men and 19% for women by Kaplan-Meier analyses, versus 21% for men and 11% for women by Framingham risk equation," Dr. Tsang's team explains.
That is, atrial fibrillation conferred additional risk for coronary events "beyond conventional risk prediction in women only," the investigators point out. Furthermore, they found, the excess mortality risk associated with coronary events after the occurrence of AF was greater in women.
Am J Med 2007;120:357-363.
# posted by roodbont @ 2:25 AM 
