Saturday, May 05, 2007
Ca en vitamine D in the elderly
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High Calcium, Vitamin D Intake in the Elderly May Have a Down Side
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# Rozerem™ (ramelteon) 8-mg tabletsView indications, efficacy data, and safety data. Full Prescribing Information.
By Megan Rauscher
NEW YORK (Reuters Health) May 01 - In one of the first studies to examine the relationship between diet and brain lesions, researchers observed a significant positive correlation between higher calcium and vitamin D intakes and total brain lesion volume on MRI in a group of elderly adults.
"Our finding of a relationship between brain lesions and consumption of both calcium and vitamin D raises the question about a possible downside to high intakes of these nutrients," Dr. Martha E. Payne of Duke University, Durham, North Carolina, told Reuters Health.
"Since our study was cross-sectional, we cannot conclude that calcium or vitamin D caused the brain lesions that we found. However, we hypothesize that our findings may be due to vascular calcification, whereby calcium is taken up into the blood vessel walls," Dr. Payne said.
She and colleagues assessed calcium and vitamin D intakes by food frequency questionnaires and MRI scans in 232 elderly men and women (average age, 71 years).
All of the subjects displayed some brain lesions of varying sizes but those reporting the highest intakes of calcium and vitamin D were significantly more likely to have higher total volume of brain lesions as measured across several MRI scans.
These positive associations remained significant in two separate multivariable models controlling for age, hypertension, diabetes, heart disease, and depression. In a multivariable model containing both calcium and vitamin D, only vitamin D remained significantly positively associated with lesion volume.
Dr. Payne noted that "higher intakes of calcium and vitamin D have been promoted in recent years as a way to prevent bone loss with aging. We are concerned that some of this extra calcium may end up in the blood vessel walls rather than the bone. This may be a particular problem for individuals with renal disease since calcium excretion may be impaired," she said.
"A longitudinal study," Dr. Payne concludes, "is urgently needed in order to determine if calcium and vitamin D lead to vascular calcification and brain lesions in the long term."
She reported the study findings at a meeting of the American Society for Nutrition, part of Experimental Biology 2007 underway in Washington, DC.
* Email ThisEmail This
Publication Logo
High Calcium, Vitamin D Intake in the Elderly May Have a Down Side
Information from Industry
# Rozerem™ (ramelteon) 8-mg tabletsView indications, efficacy data, and safety data. Full Prescribing Information.
By Megan Rauscher
NEW YORK (Reuters Health) May 01 - In one of the first studies to examine the relationship between diet and brain lesions, researchers observed a significant positive correlation between higher calcium and vitamin D intakes and total brain lesion volume on MRI in a group of elderly adults.
"Our finding of a relationship between brain lesions and consumption of both calcium and vitamin D raises the question about a possible downside to high intakes of these nutrients," Dr. Martha E. Payne of Duke University, Durham, North Carolina, told Reuters Health.
"Since our study was cross-sectional, we cannot conclude that calcium or vitamin D caused the brain lesions that we found. However, we hypothesize that our findings may be due to vascular calcification, whereby calcium is taken up into the blood vessel walls," Dr. Payne said.
She and colleagues assessed calcium and vitamin D intakes by food frequency questionnaires and MRI scans in 232 elderly men and women (average age, 71 years).
All of the subjects displayed some brain lesions of varying sizes but those reporting the highest intakes of calcium and vitamin D were significantly more likely to have higher total volume of brain lesions as measured across several MRI scans.
These positive associations remained significant in two separate multivariable models controlling for age, hypertension, diabetes, heart disease, and depression. In a multivariable model containing both calcium and vitamin D, only vitamin D remained significantly positively associated with lesion volume.
Dr. Payne noted that "higher intakes of calcium and vitamin D have been promoted in recent years as a way to prevent bone loss with aging. We are concerned that some of this extra calcium may end up in the blood vessel walls rather than the bone. This may be a particular problem for individuals with renal disease since calcium excretion may be impaired," she said.
"A longitudinal study," Dr. Payne concludes, "is urgently needed in order to determine if calcium and vitamin D lead to vascular calcification and brain lesions in the long term."
She reported the study findings at a meeting of the American Society for Nutrition, part of Experimental Biology 2007 underway in Washington, DC.
# posted by roodbont @ 12:24 PM 
