Wednesday, June 20, 2007
cholesterol
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Selection from: LDL-C -- How Low Should You Go?
LDL-C -- How Low Should You Go? CME/CE
William Virgil Brown, MD Disclosures
Introduction
In the United States, more than 1 million deaths each year are attributable to cardiovascular disease (CVD).[1] Currently, CVD affects over 70 million Americans, 27 million of whom are older than 65 years of age.[1] By the year 2010 there will be 40 million Americans over the age of 65; as the population ages, the incidence of CVD is expected to rise exponentially. In recent years, there has been a growing awareness of the importance of evaluating multiple risk factors and pathways when assessing and treating an individual's risk for CVD.[2] Dyslipidemia has been identified as one of the leading risk factors for coronary heart disease (CHD), stroke, and peripheral vascular disease (PVD). According to the World Health Organization, elevated cholesterol levels are estimated to cause 56% of global CHD and 18% of global cerebrovascular disease.[3]
Studies suggest that a 10% decrease in total cholesterol levels would result in an estimated 30% reduction in the occurrence of CVD if sustained over a lifetime.[4] Low-density lipoprotein cholesterol (LDL-C) accounts for approximately 60% to 70% of total serum cholesterol, and plays a central role in the development of atherosclerosis and CVD. In 1988, the National Cholesterol Education Program (NCEP) in the United States identified LDL-C as the primary target of cholesterol-lowering therapy. Their guidelines for LDL-C included goals adjusted according to the total impact of other CHD risk factors.[5] Over the past 20 years, with continued research into the benefit of LDL-C reduction, the goals for LDL-C have been reduced repeatedly for those individuals considered to be at very high risk.[6,7] In those considered appropriate for drug treatment, the reduction should achieve at least a 30% reduction from the baseline level. The "optimal LDL-C" for all adults in the United States was initially recommended to be < 130 mg/dL but in 2001, this was reduced to < 100 mg/dL.[7] (Figure 1)
ATP Classification of LDL.
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Selection from: LDL-C -- How Low Should You Go?
LDL-C -- How Low Should You Go? CME/CE
William Virgil Brown, MD Disclosures
Introduction
In the United States, more than 1 million deaths each year are attributable to cardiovascular disease (CVD).[1] Currently, CVD affects over 70 million Americans, 27 million of whom are older than 65 years of age.[1] By the year 2010 there will be 40 million Americans over the age of 65; as the population ages, the incidence of CVD is expected to rise exponentially. In recent years, there has been a growing awareness of the importance of evaluating multiple risk factors and pathways when assessing and treating an individual's risk for CVD.[2] Dyslipidemia has been identified as one of the leading risk factors for coronary heart disease (CHD), stroke, and peripheral vascular disease (PVD). According to the World Health Organization, elevated cholesterol levels are estimated to cause 56% of global CHD and 18% of global cerebrovascular disease.[3]
Studies suggest that a 10% decrease in total cholesterol levels would result in an estimated 30% reduction in the occurrence of CVD if sustained over a lifetime.[4] Low-density lipoprotein cholesterol (LDL-C) accounts for approximately 60% to 70% of total serum cholesterol, and plays a central role in the development of atherosclerosis and CVD. In 1988, the National Cholesterol Education Program (NCEP) in the United States identified LDL-C as the primary target of cholesterol-lowering therapy. Their guidelines for LDL-C included goals adjusted according to the total impact of other CHD risk factors.[5] Over the past 20 years, with continued research into the benefit of LDL-C reduction, the goals for LDL-C have been reduced repeatedly for those individuals considered to be at very high risk.[6,7] In those considered appropriate for drug treatment, the reduction should achieve at least a 30% reduction from the baseline level. The "optimal LDL-C" for all adults in the United States was initially recommended to be < 130 mg/dL but in 2001, this was reduced to < 100 mg/dL.[7] (Figure 1)
ATP Classification of LDL.
# posted by roodbont @ 2:52 PM 
