Archief Roodbont

Summary

Introduction: Statins have diverse anti-inflammatory effects in addition to their lipid-lowering ability. This study assesses the rate of chronic obstructive pulmonary disease (COPD) exacerbation and intubations in patients taking statins.
Methods: This is a retrospective cohort study of 185 patients with COPD exacerbation, with a 1-year follow-up. Outcomes examined were repeat hospitalisation and intubations for COPD exacerbation. Baseline characteristics for which the p-value was ≤ 0.10 were considered as covariates for inclusion in a multivariate model.
Results: The statin group had fewer episodes of exacerbation and required intubation fewer times than the subjects not receiving statins (p <>2 agonists as a covariate were 3.01 (CI: 1.46-6.10) for exacerbation and 8.89 (CI: 3.67-21.32) for intubation. Time to outcome during the observation period was reduced by statins with the hazard ratio (HR) for exacerbation of 0.19 (CI: 0.06-0.14); HR for statins reducing intubation was 0.14 (95% CI: 0.10-0.30).
Conclusions: These data suggest that the use of statins may be associated with lower incidence of both exacerbations and intubations in patients with COPD.

# posted by roodbont @ 10:53 AM